Meyer R. Rosen, Editor-in-Chief
President, Interactive Consulting Inc.
Mr. Rosen is a Chartered Chemist and Fellow of the Royal Society of Chemistry (London); a Fellow of the American Institute of Chemists and both a Nationally Certified Professional Chemist and Certified Professional Chemical Engineer. He is a member of the U.S. Society of Cosmetic Chemists (SCC) & the American Institute of Chemical Engineers. Meyer serves as an Advisor for David Smith, Executive Director of the SCC Advisory Committee. He is also Editor for U.S. & Canada and Editor-in-Chief for North and Latin America for EuroCosmetics Magazine in Germany. Mr. Rosen is Editor of the Delivery System Handbook for Personal Care and Cosmetic Products and Editor-in-Chief of Harry’s Cosmeticology, 9th Edition.

Monday, April 4, 2016

New Focus Book: Handbook of Skin Anti-Aging Theories for Cosmetic Formulation Development - Navin M. Geria

(Harrys Cosmeticology 9th Ed.)

ISBN-13/EAN: 9780820601847
Book - Paperback
Pub Date: April 2016
208 pages

Editor: Navin M. Geria, Doctors Skin Prescription (DSP), 

Authors: - Howard Murad, MD - 
Shyam Gupta, Ph.D. Bioderm Research - 
Linda Walker, CoValence, Inc. - 
Karl Lintner, PhD Kal’idees S.A.S - 
Edward Pelle, Estee Lauder Research Laboratories; - Nadine Pernodet, New York University School of Medicine - 
Rebecca Gadberry UCLA - 
Dr. Barry Chase DDS

This focus book covers:-
Part 5 Anti-Aging

Part 5.0

Fundamentals of Skin Anti-Aging Overview

Navin M. Geria, Doctors Skin Prescription (DSP), Senior Technical Advisor & Principal
DSP- Doctors Skin Prescription
34 Mountainview Road, Warren, NJ 07059 

Howard Epstein Ph.D., EMD Chemicals, Philadelphia, PA

Part 5.1

Theories of Aging
Skin Anti-Aging: At the Tipping Point

Navin M. Geria, Doctors Skin Prescription (DSP), Senior Technical Advisor & Principal
DSP- Doctors Skin Prescription
34 Mountainview Road, Warren, NJ 07059

Table of Contents:

5.1.1 Theories of Aging

a. Wear and Tear Theory (Immunological Theory)
b. The Neuro-Endocrine Theory
c. The Genetic Control Theory
d. The Free Radical Theory
e. Mitochondrial Theory
f. Waste Accumulation Theory
g. Hayflick Limit Theory
h. Death Hormone Theory
i. Caloric Restriction Theory
j. The Cross-Linking Theory
k. The Telomerase Theory 
l. Glycation Theory
m. Mutation Accumulation and DNA/RNA Damage
n.Deficient Immune System/Autoimmune Theory
o. Inflammation Theory


Part 5.2

The Cellular Water Principle


Howard Murad, MD
2121 Rosecrans Avenue, 5th Floor
El Segundo, CA 90245

Table of Contents:

Theories of Aging and Cellular Water

5.2.1 What is aging, from a physiological perspective?
5.2.2 Why do we age?
5.2.3 Water loss and membrane hypothesis of aging
5.2.4 The Science of Cellular Water

Part 5.3 

Anti-Senescence: Achieving the Anti-Aging Effect by Managing Cellular Functions


Shyam Gupta, Ph.D.
Bioderm Research

Linda Walker
CoValence, Inc.

Table of Contents:

5.3.1 Role of Cellular Senescence and Apoptosis in Skin Aging

5.3.2 Role of Enzyme Dysfunction in Skin Aging

a. Oxidative Stress and Free Radicals
b. Peroxisomes
c. Immunosenescence
d. Advanced Glycation End Products (Ages)
e. Proteasomes in Cellular Anti-Senescence
f. Mitochondrial Free Radical Theory of Aging (Mfrta)

5.3.3 Anhydrobiosis and Skin Aging

5.3.4 Osmoprotection, Cellular Anti-Senescence, and Skin Anti-Aging

a. Hyperosmarity, Inflammation, and Cellular Senescence
b. Chemical Basis of Hyperosmarity

5.3.5 New Peptide Derivatives for Anti-Senescence and Skin Anti-Aging

a. Chemical Discovery
b. Formulation Methodology

5.3.6 Consumer Perception and Marketing of Enzyme Biology-Based Skin Care Products


Part 5.4 

Glycation, Proteasome Activation, and Telomere Maintenance

Karl Lintner, PhD
President of Kal'idees S.A.S.

Table of Contents:

5.4.1 Glycation

a. Measurement of AGEs
b. Prevention and/or Reversal of Glycation/Glycoxidation
c. In vitro data
d. Ex vivo data on explants
e. In vivo studies
f. Conclusion 

5.4.2 The Proteasome

a. Introduction
b. Cosmetic approach to proteasome activity
c. The study of the LC3-II protein 
d. Caveat

5.4.3 Telomeres

a. Introduction
b. Telomere length and aging 
c. Senescence
d. Cosmetic ideas on telomere maintenance


Part 5.5 

Sirtuins and Skin

Edward Pelle, Este Lauder Research Laboratories; Melville, New York
Nadine Pernodet, Environmental Medicine, New York University School of Medicine

Table of Contents 

5.5.1 Introduction to sirtuins 
5.5.2 Organelle-specific biochemistry of sirtuins 
5.5.3 Sirtuin response to environmental changes 
5.5.4 Application of sirtuins to anti-aging skin care 

Part 5.6

Epigenetics of Skin Aging


Rebecca James Gadberry
Senior Instructor & Program Coordinator,
Cosmetic Sciences, UCLA Extension
Consultant, Skin Care Strategy, Brand & Product Development

Table of Contents:

5.6.1 The Human Genome Project Gives Birth To The Epigenetic Revolution 
5.6.2 Epigenetics Defined

5.6.3 Two Primary Epigenetic Mechanisms

1. DNA methylation
2. Chromatin remodeling and histone modification

5.6.4 Epigenetic Links To Aging
5.6.5 Epigenetics And Aging Skin 
5.6.6 Epigenetics Mechanisms In DNA Damage and Repair 
5.6.7 Cosmetic Ingredients As Epigenetic Modifiers 
5.6.8 Nutriepigenetics: How Diet Alters the Epigenome
5.6.9 Epigenetics: The Unifying Theory Of Aging?
5.6.10 What the Future Holds

List of Figures

Part 5.7

Chronobiology of the Skin
Skin Circadian Rhythm and Clock Genes: 
A New Approach to Slowing Down the Aging Process


Nadine Pernodet, Ph.D. Vice President of Skin Biology Research

Edward Pelle, Ph.D. Director, Skin Biology Research
Este Lauder Research Laboratories 
Melville, NY, US

Table of Contents:

5.7.1 Introduction to Circadian Rhythm and Clock Genes
5.7.2 Desynchronization: Causes and Impact
5.7.3 Skin Circadian Rhythm

Part 5.8 

Stress, Sleep and Epigenetic Orthodontics: 
New Directions for Non-Surgical Skin Anti-Aging

Dr. Barry Chase DDS

Table of Contents:

Stress, Sleep and Epigenetic Orthodontics: 
New Directions for Non- Surgical Skin Anti-Aging

5.8.1 Sleep, Sleep Deprivation, Sleep Disorders, and Skin Aging 

a. Normal SleepSleep Stages and Sleep Cycles:
b. Sleep Latency
c. Sleep Stage N1
d. Sleep Stage N2
e. Sleep Stage N3
f. Rapid Eye Movement (REM) Sleep
g. Sleep Disorders, Chronic Stress, and the Impact on Aging and Skin
h. The Pathophysiology of Stressthe Hyper-Arousal of the Autonomic Nervous System
i. Sleep and Chronic Stress
j. Insomnia
k. Obstructive Sleep Apnea

5.8.12 Sleep, Aging, and Aging Skin

a. Sleep Quality and Sleep Deprivation
b. Circadian Rhythm
c. Sleep, Human Growth Hormone: Aging and Skin
d. Chronic Stress and Sleep; Cortisol, Epinephrine, Aging, and Skin
e. Epinephrine and the Skin
f. Free Radicals, Sleep and Aging

5.8.13 Therapy

a. Insomnia 
b. Non-medical Cognitive Behavioral Therapy 
c. Sleep Hygiene
d. Obstructive Sleep Apnea (OSA) and Aging
e. C-PAP Therapy
f. Oral Appliance Therapy (OAT)


Part 5.8.2
Epigenetic Orthodontics and Dento-Facial Orthopedics:

Non-surgical Facial Esthetic Therapy

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